NIACINAMIDE FOR CURING DEPRESSION, 33

DRUG ADDICTION, PELLAGRA,

ALZHEIMER’S, ARTHURITIS, JOINT

DYSFUNCTION, ADHD, Schizophrenia AND

REDUCTION OF PAIN, and cured my bone on bone knee and shoulder pain without replacement Operation.   

My hands looked like this and 4 doctors did not know I had Pellagra.  I found I had Pellagra on the internet and am now totally cured without my Dr’s recommended knee or shoulder replaced and the pain is gone. Pellagra would have soon killed me like it did to over 100,000 people around 1900. Learn more Paul 810-736-8873 my web pobrien48.com vitamin.

IIf our Government required about four or five times as much niacinamide  as it is now require a fatty food manufacturers to put in our wheat products this would help eliminate a lot of  prison population

 

Vitamin B3 comes in many forms niacin must be changed  by the body into niacinamide by the liver.  in the process it causes hot flashes and overworked the liver causing liver health problems.

Niacinamide cures Depression, Stiff  joints, ADHD, anxiety disorders and obsessive-compulsive personality symptom, treatment of fatigue,  Schizophrenia and Psychosis Anxiety and mood swings, control of blood sugar levels, Parkinson's disease, stop dementia, dermatitis and get back up to 100 percent of your range of motion and greatly reduced  pain, eliminate need and shoulder replacement & stiffness. It dramatically reduces violence.  Helps you stop Smoking & Drinking.  Purchase Niacinamide here; take 3 AM and 3 PM   .

Everyone in America should be taking at least two 500 mg of Niacinamide per day. Warning if you stop the Niacinamide the pain and stiffness will return. When our government in 1911 required food manufacturers to add a small amount of niacin to wheat products, half the people left the insane asylums. Dr. Huffer cured 90% of schizophrenic with niacinamide.

 

A Dr. told me, he was taught that pellagra no longer exists since they added a tiny amount of niacinamide to all wheat products. What he was taught was definitely wrong

Collagen rebuild cartridge between the joints of your knees, hip and shoulder eliminating pain; so everyone should be taking collagen..

  • K2 Mk7 is the only vitamin known to prevent and reverse atherosclerosis, COPD and dramatically  reduce Alzheimer’s.

Should you get your knee or hip replaced? No!!!   There is a much better solution.  I had severe pain in my knee for over 40 years and my shoulder had hunks of bursitis making my shoulder very difficult to move and very painful. By taking six niacinamide tablets each day, two 50,000 units per week of vitamin D3, three 500 mg capsules  calcium and three magnesium 500 mg, one K2-Mk7 one selenium 200 mg each day I gained 100% range of motion without pain. I am now dancing 3 to 5 times a week.

Rough raw skin on hands is a sign of a lack of niacinamide and an indication that you have Pellagra. The possible biochemical reasons for niacin amide's effectiveness might be related to the correction of subclinical pellagra, the correction of an underlying vitamin B3 dependency disorder, its benzodiazepine-like effects, its ability to raise serotonin levels & dopamine, or its ability to modify the metabolism of blood lactate (lactic acid). Comment: Paul: My hands looked much younger, with no roughness or cracking.

The physical therapist said I had the worst range of motion he had seen in 21 year in practices. All my joints hurt and my left arm was stiff due to bursitis. I walked stooped over and was walking with a cane. I was going into a fetal possession and getting worse.  I took Niacinamide and the proper amounts of other vitamins and minerals.  At 83 in 2017 I now have no sore joints and can run.  When someone tell you vitamins and minerals don't work show them the above  photos. Niacinamide gives 100% range of motion to most people.

Another thing you should know is without enough vitamin K2 calcium cannot get into your bones and instead plugs up your arteries, your veins, and the heart valves producing bone like material called hardening of the arteries. If you take vitamin K2-MK 7you will never need a heart bypass, stints or a heart valve replacement, hip fractures. Taking what I’m taking would eliminate most hospitals, most doctors’ offices, most assisted living homes, and most prisons.

Vitamin Niacinamide can help with the following: Alzheimer's Disease An over-the-counter vitamin in high doses prevented memory loss in mice with Alzheimer's disease, and UC Irvine scientists now are conducting a clinical trial to determine its effect in humans.

Nicotinamide, a form of vitamin B3, lowered levels of a protein called phosphorylated tau that leads to the development of tangles, one of two brain lesions associated with Alzheimer's disease. The vitamin also strengthened scaffolding along which information travels in brain cells, helping to keep neurons alive and further preventing symptoms in mice genetically wired to develop Alzheimer's.

"Nicotinamide has a very robust effect on neurons," said Kim Green, UCI scientist and lead author of the study. "Nicotinamide prevents loss of cognition in mice with Alzheimer's disease, and the beauty of it is we already are moving forward with a clinical trial."

Nicotinamide, they found, led to an increase in proteins that strengthen microtubules, the scaffolding within brain cells along which information travels. When this scaffolding breaks down, the brain cells can die. Neuronal death leads to dementia experienced by Alzheimer's patients.

"Microtubules are like highways inside cells. What we're doing with nicotinamide is making a wider, more stable highway," Green said. "In Alzheimer's disease, this highway breaks down. We are preventing that from happening."

The study appeared online Nov. 5, 2008 in the Journal of Neuroscience.

 Diabetes Type I  Niacinamide improves ATP mitochondrial production in the face of diabetogenic chemicals and thus allows Islet cells to stay alive. The Type I honeymoon period can just be extended 12-18 months and insulin requirements may be less.

Mental  Anxiety The textbook description of anxiety neurosis exactly matches the symptoms of vitamin B3 (niacin) deficiency: hyperactivity, depression, fatigue, apprehension, headache, and insomnia. It has been shown in animals to work in the brain in ways similar to drugs such as benzodiazepines (Valium-type drugs) that are used to treat anxiety. One study found that niacinamide (not niacin) could help people get through withdrawal from benzodiazepines, which is a common problem. A reasonable amount of niacinamide to take for anxiety, according to some doctors, is up to 500mg four times per day.

Niacinamide locks onto the same receptor sites in the brain as do tranquilizers such as Valium, OxyContin and is a natural tranquilizer. The manufacturer of valium is also the world’s largest manufacturer of niacinamide. [Nature 278: pp.563-65,1979] Valium was developed from niacinamide.

  Poor Sense of Humor Early signs of Vitamin B3 (Niacin) depletion include the loss of a sense of humor.

-Skeletal  Osteoarthritis Results may be seen in 3-4 weeks with a plateau of improvement reached at 12 weeks. The dose may be lowered at this time but if discontinued, the symptoms will come back. Intake of 500mg 3-6 times daily has commonly been recommended. Sustained release forms require less frequent dosing.[ Inflamm Res 1996;45: pp.330-4]

Wayne Jonas from the NIH Office of Alternative Medicine conducted a 12 week, double-blind, placebo controlled study of 72 patients to assess the validity of Dr. Kaufman’s earlier work with niacinamide and osteoarthritis. Using a dose of 3 grams of niacinamide per day, they found that overall disease severity was reduced by 29%, inflammation was reduced by 22% and the use of anti-inflammatory medication was reduced by 13%. Patients taking the placebo, on the other hand, either had no improvement, or actually worsened.

  Cirrhosis of the Liver Niacinamide can protect the liver against alcohol-induced damage.

  Diabetes Type II  Niacinamide improves ATP mitochondrial production in the face of diabetogenic chemicals and thus allows insulin-producing cells of the pancreas to stay alive longer. In one trial, newly diagnosed patients were given niacinamide at 25mg per kg of body weight. This restored the insulin-producing cells of the pancreas in some, slowed the cellular destruction in others and left a number no longer diabetic. Use in diabetic patients should always be monitored by a physician as insulin requirements may change.

  Decreased Risk of Alzheimer's / Dementia An over-the-counter vitamin in high doses prevented memory loss in mice with Alzheimer's disease, and UC Irvine scientists now are conducting a clinical trial to determine its effect in humans.

Nicotinamide, a form of vitamin B3, lowered levels of a protein called phosphorylated tau that leads to the development of tangles, one of two brain lesions associated with Alzheimer's disease. The vitamin also strengthened scaffolding along which information travels in brain cells, helping to keep neurons alive and further preventing symptoms in mice genetically wired to develop Alzheimer's.

"Nicotinamide has a very robust effect on neurons," said Kim Green, UCI scientist and lead author of the study. "Nicotinamide prevents loss of cognition in mice with Alzheimer's disease, and the beauty of it is we already are moving forward with a clinical trial."

Scientists found that the nicotinamide-treated animals had dramatically lower levels of the tau protein that leads to the Alzheimer's tangle lesion. The vitamin did not affect levels of the protein beta amyloid, which clumps in the brain to form plaques, the second type of Alzheimer's lesion.

Nicotinamide, they found, led to an increase in proteins that strengthen microtubules, the scaffolding within brain cells along which information travels. When this scaffolding breaks down, the brain cells can die. Neuronal death leads to dementia experienced by Alzheimer's patients.

"Microtubules are like highways inside cells. What we're doing with nicotinamide is making a wider, more stable highway," Green said. "In Alzheimer's disease, this highway breaks down. We are preventing that from happening."

Click Here to learn Nioctinamide reduces pain and does a lot more

Niacinamide (Vitamin B3) for the treatment of arthritis, stiff  joints, anxiety disorders and obsessive-compulsive personality symptom plus a cure for many other things.

Niacinamide  is For the treatment of Arthritis , stiff  joints, ADHD, anxiety disorders and obsessive-compulsive personality symptom, treatment of fatigue,  Schizophrenia and Psychosis Anxiety and mood swings control of blood sugar levels Parkinson's disease, stop dementia, dermatitis and get back up to 100 percent of your range of motion and greatly reduced  pain & stiffness  Helps you stop Smoking & Drinking.  Everyone in America should be taking at least two 500 mg of Niacinamide per day. Warning if you stop the Niacinamide the pain and stiffness will return.

Comment: Dr Edward Christy MD, Davison Mi. said:  "I read what you gave me on Niacinamide. I left my clinic and went to Wal-Mart got some and took it. Wow It really worked".

Comment: Dale  Rouse, After more than 18 years of knee pain was cured in 3 days,  I was very stiff & had problems walking. The stiffness is gone & I am walking great. I am 56 and the doctor said he expected to see me in a wheel chair in a few years. Doctors don't check B3 levels with blood tests. It costs over $1000 & is not covered by insurance. The pain and stiffness is gone.

Comment: Paul O'Brien: A physical therapist after 30 weeks of therapy said I was the stiffest he had seen in 21 years. My knee was sour from 1953 and was getting worse. I was walking with a cane and in much pain. Doctors said  I  should get a knee and  shoulder replacement,. Niacinamide cure these problems without operations. I now dance 3 to 4 nights per week without pain.

"Adequate" dosage of niacinamide is defined as that clinically safe dosage of niacinamide which, when ingested in divided doses throughout the day by a person with joint dysfunction whose ordinary diet is not inadequate in protein or calories, and whose joints are not subjected to excessive mechanical joint injury, will effect in time what the writer has considered to be a satisfactory pattern of increasing values of the Joint Range Index. The pattern of recovery from joint dysfunction in response to niacinamide therapy, and the numerical limits of increments in the value of the Joint Range Index which are considered to be satisfactory for the first month of therapy and for succeeding months, are described on page 24.

“Optimal” dosage of niacinamide is defined as that clinically safe dosage niacinamide which, when ingested in divided doses during the day by a person with joint dysfunction, would permit the most rapid recovery in joint function, as demonstrated by the largest possible increments in the values of the Joint Range Index in the shortest possible period of time. At present, the optimal dosage of niacinamide for the treatment of joint dysfunction has not been determined clinically, although it is hoped to approximate such a dosage level eventually. Since adequate dosages of niacinamide have given clinically satisfactory results without producing any untoward symptoms or signs of acute or chronic toxicity, no attempt has been made in this study to determine the optimal level of niacinamide therapy in the treatment of the various clinical grades of joint dysfunction.

   However, as the higher dosage levels of niacinamide have been cautiously explored in the past 22 months, it has been found in severe and extremely severe joint dysfunction that divided doses of niacinamide totaling 4 or 5 grams (4,000-5,000 mg) per 24 hours are therapeutically superior to the lower dosage schedules which previously had been considered adequate. Even these higher dosage levels of niacinamide may not be optimal for the treatment of joint dysfunction.

The optimal dosage of niacinamide for the treatment of joint dysfunction, as well as the limit of human tolerance for niacinamide, can be established only in those medical centers equipped to provide careful clinical supervision, and to conduct such chemical, metabolic and clinical laboratory studies as would reveal the earliest signs of toxicity, should these occur with the administration of progressively higher dosage levels of niacinamide.

DESCRIPTION OF JOINT DYSFUNCTION AND ITS TREATMENT FOR THE PATIENT

  Since the cooperation of the patient is a prerequisite for the successful therapy of joint dysfunction, it was found desirable and necessary before treatment of joint dysfunction was instituted to discuss with the patient his various clinical problems (including the dynamic nature of joint dysfunction, and its response to niacinamide treatment, and the dynamic nature of certain complicating syndromes, and their appropriate treatment), and the therapeutic goals. During the course of therapy, it may become necessary to review and amplify this discussion for the benefit of the patient as various clinical problems arise.

  Joint dysfunction is the articular aspect of a generalized, usually slowly progressive metabolic disorder which is corrected in time by adequate niacinamide therapy. Since the retrograde changes in tissue structure and function which characterize this disorder occur insidiously over a period of years, many of its symptoms and signs are incorrectly attributed by laymen and physicians alike to the so-called "normal" aging process. But  these retrograde changes in morphology and function of bodily tissues are usually  reversible in time when adequate levels of niacinamide are supplied continuously to bodily tissues. The patient who takes continuously adequate amounts of niacinamide experiences, in addition to improvement in joint function, an improvement in his general health.

  Theoretically, optimal nutrition must be continuously available to bodily tissues to ensure the best possible structure and function of tissues (104) (108). While we do not know what constitutes optimal nutrition, it has been demonstrated empirically that even persons eating a good or excellent diet according to present-day standards exhibit measurable impairment in ranges of joint movement which tends to be more severe with increasing age (see page 153). It has also been demonstrated that when such persons supplement their good or excellent diets with adequate amounts of niacinamide, there is, in time, measurable improvement in ranges of joint movement, regardless of the patients' ages. In general, the extent of recovery from joint dysfunction of any given degree of severity depends largely on the duration of adequate niacinamide therapy (see pages 187 and 188).

  With the ingestion of adequate amounts of niacinamide continuously for a sufficient period of time, a patient whose ordinary diet is not inadequate in protein or calories, whose joints are not subjected to excessive mechanical trauma, will recover from joint dysfunction at the satisfactory rate of 6.0 to 12.0 Joint Range Index units, or better, in the first month of therapy, and 0.5 to 1.0 Joint Range Index unit, or better, for each month of therapy thereafter, until a Joint Range Index of 96-100 is reached. (Rarely, when a patient has one or more ankylosed joints, he may have no appreciable active or passive movement of these ankylosed joints, even after two years of adequate niacinamide therapy, although his other joints recover the full ranges of movement in response to such therapy. In such cases, the Joint Range Index cannot reach 96-100; e.g., when one wrist is ankylosed and has not shown increased movement in response to niacinamide therapy, the maximum Joint Range Index attainable is 90.9; and when both wrists are ankylosed, the maximal Joint Range Index attainable is 81.8.)

  In general, the more severe and more chronic the patient's joint dysfunction, the slower is the rate of recovery in response to adequate niacinamide therapy, and the slower his subjective appreciation of improvement. The rate of recovery for each patient must be established empirically from serial determinations of the Joint Range Index. In order to ensure a continuously satisfactory rate of recovery from joint dysfunction, the physician must re-examine the patient at intervals during the course of niacinamide therapy. Whenever a patient taking the amounts of niacinamide prescribed by the physician, and eating a good or excellent diet, fails to make satisfactory improvement in his Joint Range Index, in the absence of excessive mechanical joint injury the niacinamide schedule must be revised upward to that level which permits satisfactory improvement. Failure of the patient to take niacinamide as directed will result in failure to improve at a satisfactory rate.

  When a patient has joint dysfunction associated with obvious arthritic deformities, he is told that the physician cannot predict whether or not in his case articular deformities will resolve with adequate niacinamide therapy. However, in response to adequate niacinamide therapy for a sufficient period of time, other patients have shown partial or complete resolution of their arthritic joint deformities. Some patients with arthritic deformities show resolution of some of their joint deformities, but not of others. Only careful observation of the patient's deformities on serial re-examinations will indicate whether or not his deformities are resolving in response to adequate niacinamide therapy. In most instances, the rate of resolution of the deformities will be slow, if it occurs at all.

  It cannot be predicted whether or not a given joint that appears to be completely ankylosed clinically will recover any degree of movement. It has been observed many times that joints appearing to be clinically ankylosed prior to therapy tend to have partial or complete recovery of movement in response to adequate niacinamide therapy, although some ankylosed joints have not shown any degree of movement as a result of therapy during an observation period of several years. In response to adequate niacinamide therapy over a sufficient period of time some patients have partial or complete recovery of movement in some of their ankylosed joints, but not in others. Only careful observation of the ranges of joint movement on serial re-examinations will demonstrate whether or not a given ankylosed joint can recover any degree of movement in response to adequate niacinamide therapy.

  In general, in the absence of complicating factors, the higher the patient's Joint Range Index rises in response to adequate niacinamide therapy, the fewer articular symptoms he will have; and the better he will feel. However, even though the Joint Range Index increases satisfactorily in response to adequate niacinamide therapy, the patient may not feel well because of complicating syndromes which are not on the basis of aniacinamidosis. Careful clinical study is necessary in order to establish the etiology of whatever complicating syndromes may be present and, with appropriate therapy, the patient is likely to become free from articular symptoms and to feel well. However, at any time symptoms of bodily discomfort may recur which must be studied and given appropriate treatment as promptly as possible, if the patient is to feel well again. While the patient may obtain temporary relief from articular and other symptoms through the use of analgesics, narcotics, sedatives, antihistamines and local anesthetics, only adequate treatment of joint dysfunction and the complicating syndromes is likely to give more lasting benefits.

  In order to assess the effects of niacinamide therapy on joint dysfunction and on the patient's general status, the patient is usually re-studied one month after continuous niacinamide therapy has been instituted. If good progress in recovery from joint dysfunction is noted at that time, he is reexamined in two months, and thereafter every three to six months. For the most part, this schedule of re-examination is found to be satisfactory for the supervision of the therapeutic program of patients presenting the chronic problems of joint dysfunction, although when the individual's problems are of unusual complexity, or when intercurrent problems arise, the time interval between visits is shortened.

  When a patient with joint dysfunction fails to make the anticipated progress in response to niacinamide therapy, he is asked if he has taken the medication as prescribed; if not, he is urged to do so. (When a patient has taken multiple vitamin capsules as prescribed and has not made satisfactory improvement in his Joint Range Index in response to such therapy, the druggist is asked how the vitamin powders were compounded. The clinical effectiveness of niacinamide seems to be lessened when niacinamide is mixed with ascorbic acid by vigorous trituration, since this favors inter-molecular reactions between niacinamide and ascorbic acid in the dry powder state. The occurrence of such inter-molecular reactions between niacinamide and ascorbic acid is hindered by the preliminary admixture of each dry powder separately with a small amount of calcium stearate (0.2%) before the final admixture by sieving.)

  It is always emphasized that the patient must take his medication continuously as prescribed until such time as the supervising physician may decide, on the basis of objective clinical evidence, that it is necessary to increase the level of niacinamide therapy in order to produce continuously satisfactory improvement in the Joint Range Index.

   However, certain factors other than the ingestion of inadequate amounts of niacinamide may tend to depress the Joint Range Index. These include (a) transient or persistent mechanical joint injury resulting from unusual or physical exertion (see page 79) or from psychogenically sustained hypertonia of somatic muscle (see page 115), (b) rapid and excessive gain in weight to obesity levels, (c) excessive ingestion of alcohol, (d) inadequate dietary protein. When any of these factors is operative, it is of limited value to increase the amounts of niacinamide taken by the patient in an effort to effect satisfactory improvement in the Joint Range Index. Instead, treatment should be directed toward lessening the degree of mechanical joint injury, reducing the patient's weight to the normal range, interdicting alcohol, and increasing the protein intake to adequate levels, respectively.

   When indicated, the physician describes for the patient four complicating syndromes frequently coexisting with joint dysfunction, and their treatment (see page 76). Most of the articular and non-articular symptoms of a patient with joint dysfunction which are not corrected by niacininide therapy usually originate as part of these four complicating syndromes. When the patient understands the etiologic basis of his symptoms, he will not have anxiety concerning the meaning of symptoms which would otherwise seem mysterious and alarming. The patient with joint dysfunction who has one or more of these complicating syndromes is told that he will not feel well unless joint dysfunction and these coexisting syndromes are correctly identified and successfully treated, and that in order to accomplish this, his active participation in the clinical investigation and therapeutic program is required.

TYPICAL IMPROVEMENT IN MOBILITY OF A SINGIE JOINT IN RESPONSE TO LEVELS OF NIACINAMIDE THERAPY USED PRIOR TO APRIL 1947

In serial determinations of the mobility of single joints in response to levels of Niacinamide therapy used prior to April 1947, it was found that niacinamide-induced recovery of full joint mobility was an orderly process. (Since April 1947, when higher dosage schedules of niacinamide were introduced (see page 21), there has been a marked reduction in the incidence of articular pain and discomfort upon maximal passive movement of the moveable joints during various stages of recovery from joint dysfunction.)

   There is described below typical improvement in joint mobility, as illustrated by several sequential stages occurring during niacinamide-induced recovery of full mobility of the metacarpophalangeal (knuckle) joint.

(Figure 14 is a schematic representation of maximal passive extension of the meta-carpophalangeal joint at four successive stages (a) (b) (c) (d), during the course of niacinamide-induced recovery of full joint mobility. The line touched by the head of the arrow in (a) (b) (c) (d) indicates the upper limit of painless extension. The shaded angle in (b) and (c) indicates the range of painful passive extension.)

  Figure 14(a). On the initial examination before niacinamide therapy was instituted, the metacarpophalangeal joint of the forefinger of the right hand could be extended passively to 30% of the full range of extension for this joint. No pain or discomfort was experienced by the patient during this maneuver. The examiner noted the presence of palpatory resistance from the initiation of the movement of passive extension of this metacarpophalangeal joint, and this resistance progressively increased as the joint was extended from the range of 0% to 30% of the maximal extension; the palpatory resistance at the end of the movement was graded as firm. When at the 30% level of passive extension a small increase of force in the direction of extension caused no further extension of this joint, 30% of the full range of extension was taken as the upper limit of maximum passive extension of this metacarpophalangeal joint.

  Figure 14 (b). At the end of one month of continuous, adequate niacinamide therapy, maximal passive extension of this metacarpophalangeal joint increased to 60% of the full range of extension. No pain or discomfort was experienced by the patient when the metacarpophalangeal joint was extended from 0% to 40% of the full range of extension. The patient experienced localized joint pain, often severe, as the joint was passively extended from 40% to 60% of the full range of extension. The examiner's palpatory sensation indicated that movement of the joint in passive extension was free from 0% to 40%, and that there was soft, yielding resistance which progressively increased as the finger was extended at the metacarpophalangeal joint from 40% to 60% of the full range of movement. When a further small increase of the extending force did not increase the degree of extension, 60% of the full range of extension was taken as the upper limit of passive extension of this metacarpophalangeal joint. The palpatory resistance at the end of the movement of extension was rubbery.

  Figure 14 (c).After months of continuous, adequate therapy with niacinamide, maximal passive extension of the metacarpophalangeal joint reached 100%; i.e., the full range of movement. Passive extension of the metacarpophalangeal joint from 0% to 85% was without pain or discomfort; passive extension from 85% to 100% was painful. The examiner's palpatory sensation indicated that the movement of this joint was free from 0% to 85%, and that there was soft resistance, which increased progressively with increasing extension of the metacarpophalangeal joint from the level of 85% to 100%. A small additional force in the direction of extension when the 100% level was reached did not cause further extension of this joint. The palpatory resistance at the end of the full range of movement (100%) was rubbery.

  Figure 14(d). With a longer period of continuous, adequate niacinamide therapy, it was possible to achieve full, free and painless extension of this metacarpophalangeal joint to the level of 100%. Slight additional palpatory force in the direction of extension with the joint fully extended did not increase the amount of movement beyond the full range of extension; i.e., the 100% level. The examiner's palpatory sensation indicated that the movement of extension was free from 0% to 100% of full extension, that the resistance met at the end of this movement was firm, and that the patient experienced no pain from this maneuver.

After completion of his physical examination, the patient was apprised of the normal and abnormal findings revealed by the clinical study. Where problems other than joint dysfunction existed, these were discussed, and appropriate therapeutic recommendations were made. The subject of joint dysfunction was then presented. The meaning of the numerical value of the patient's Joint Range Index was explained to him in terms of the Clinical Classification of Joint Function (see page 21), and the dynamic nature of joint dysfunction was described. The patient was told that joint dysfunction was reversible in time when appropriate therapy was taken.

All patients with joint dysfunction who elected to accept treatment were given niacinamide in suitable doses, either alone or in combination with other vitamins. When indicated the appropriate vitamins were prescribed in addition to niacinamide. The water-soluble vitamins used were never prescribed in aqueous solution, but as tablets or as dry powders in capsule form. When vitamin A was used, it was usually given in conjunction with vitamin D. Vitamin D was always given in conjunction with vitamin A; when vitamin D was administered in this study, the daily dosage rarely exceeded 6,000 U.S.P.units per 24 hours (14) (10) (38) (56) (59) (95).

Participation in the therapeutic program was entirely voluntary on the part of the patient. Some patients at the outset declined to accept treatment for their joint dysfunction. When a patient accepted therapy for his joint dysfunction, with each succeeding visit after the initial one, improvement or lack of improvement in his joint dysfunction was frankly discussed with him. No patient was chided because he was unwilling or unable to carry out the program of therapy as it was originally scheduled. Thus, because there was no “loss of face," most patients cooperated well and gave an accurate account of their deviations, if any, from the suggested therapeutic program. Some patients at the end of the first or second month of treatment, or at a later time, felt so much improved physically that they discontinued therapy for their joint dysfunction, mistakenly believing, in spite of advice to the contrary, that they were "cured," and required no further therapy or medical supervision. Some of these persons, who experienced a recurrence of their original pattern of symptoms upon premature cessation of therapy, returned subsequently for re-evaluation of their therapeutic needs. Other patients, who felt that they had not benefited from therapy for their joint dysfunction, did not continue with treatment though objectively they responded satisfactorily to adequate therapy, as shown by increasing values of the Joint Range Index on serial re-measurements.

Therapy was always individualized. In the therapeutic program introduced for the treatment of joint dysfunction, each patient served as his test object in the bio-assay of the dosage of niacinamide necessary to reverse his joint dysfunction. Therapy with niacinamide (used 


alone or in combination with other vitamins) was not deemed successful unless there continuous, objective improvement, as judged by continuously increasing values of the Joint Range Index on consecutive reexaminations. (When a patient subsists on a low-protein diet, amounts of niacinamide that would ordinarily be adequate for the treatment of his joint dysfunction prove to be inadequate for satisfactory improvement. In this case, the dosage of niacinamide is continued at the same level, but the protein level of the diet is increased to adequate levels, with subsequent satisfactory improvement in the joint dysfunction.) (118) (120) (172).

The clinical classification of joint function in terms of the numerical values of the Joint Range Index is listed below:

Clinical Classification of Joint Function
Degree of Joint Dysfunction    Joint Range index

No joint dysfunction                   96-100
Slight joint dysfunction              86-95
Moderate joint dysfunction       71-85
Severe joint dysfunction           56 -70
Extremely severe joint dysfunction 55 or less

For each clinical grade of joint dysfunction, the initial dosage schedule of niacinamide suggested below effects in time such improvement in joint dysfunction as the writer has considered to be clinically satisfactory. (However, since April 1947, it was found that dosage schedules 50-100% greater than those recommended below (particularly in the moderate, severe and extremely severe grades of joint dysfunction) are therapeutically superior, as judged by the patient's clinical response.)

 While the initial dosage may be increased as necessary during treatment, it is not decreased, even though the Joint Range Index increases in response to adequate therapy.

  The vitamins were administered orally, usually in equal doses at equal intervals during the day, and, in severe and extremely severe joint dysfunction, during the night when the patient would spontaneously awaken from sleep. In slight grades of joint dysfunction, the daily continuous ingestion of 100 mg of niacinamide after meals and at bedtime sufficed for treatment (400 mg/24 hours). Usually adequate in moderate joint dysfunction was the continuous ingestion of 150 mg niacinamide administered every 3 hours for 6 daily doses (900 mg/24 hours). In extremely severe and severe grades of joint dysfunction, 100-150 mg niacinamide were prescribed every hour (1500-2250 mg/24 hours), every hour and a half (1110-1650 mg./24 hours), or every two hours (800-1200 mg/24 hours), depending on the severity of the joint dysfunction, the more frequent schedule being used in more severe cases (97) (51).

It has been found in the treatment of joint dysfunction that the manner in which the daily dosage of niacinamide is divided has an important bearing on the the therapeutic results achieved; e.g., 300 mg niacinamide given three times daily (900 mg/24 hours) is inferior in its therapeutic action to 150 mg niacinamide administered every 3 hours for 6 daily doses (900 mg/24 hours). Therefore, to define the type of therapy used, the writer routinely records the following data: (a) the number of milligrams or units administered per dose, and (b) the total number of milligrams or units administered per 24 hours.

No untoward effects or clinical signs of toxicity were noted when niacinamide (alone or in combination with other vitamins) was administered on the above dosage schedules to individuals for short or long periods of observation. Before 1943, mild hypoglycemia had been noted clinically in a few persons when niacinamide exceeded certain dosage levels (97) (135) (51) (62), but this phenomenon has not been observed since that time.

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The purpose of this report is to highlight the potential of niacinamide for the treatment of anxiety disorders. Three patients were prescribed large pharmacological doses of niacinamide (2,000-2,500 mg per day). Each of the patients had considerable relief from their anxiety when regularly using niacinamide. The possible biochemical reasons for niacinamide’s effectiveness might be related to the correction of subclinical pellagra, the correction of an underlying vitamin B3 dependency disorder, its benzodiazepine-like effects, and its ability to raise serotonin levels & dopamine, or its ability to modify the metabolism of blood lactate (lactic acid).

Anxiety disorders are very prevalent conditions treated by primary care providers. In a recent survey of 2,316 randomly selected patients (aged eighteen-years and older) seen by general practitioners, 42.5% of all patients had evidence of a threshold/ sub-threshold psychiatric disorder.1 In the same survey, anxiety disorders were found in 19% of all patients. In a survey of 88 outpatients in an internal medicine clinic, 30% of patients had mixed anxiety features, 33% had generalized anxiety symptoms, almost half reported obsessive-compulsive personality symptoms, and about one-quarter had marked levels of worry. The investigators concluded that anxiety disorders are more common in primary care settings than what had been previously reported

Anxiety disorders are classified into various categories such as obsessive-compulsive disorder (OCD), panic disorder (PD), social phobia/social anxiety disorder (SAD), and generalized anxiety disorder (GAD). This report will not differentiate the various categories of anxiety disorders as described in the Diagnostic and Statistical

Manual of Mental Disorders.3

Considering their high prevalence, it is paramount that effective treatments are offered to patients due to the obvious suffering that accompanies anxiety disorders. Heart racing, muscular tension, sweating, flushing, nervousness, constant worry, and panic characterize some of the debilitating symptoms of anxiety disorders. It is unfortunate that many patients seeking standard (mainstream) treatment for anxiety disorders remain untreated and under diagnosed many years after their initial diagnoses, leading to unremitting impairment in functional status and quality of life.4

I evaluate and treat patients every day suffering from unremitting anxiety symptoms. In my efforts to mitigate their anxiety, I have been prescribing the amide of niacin (nicotinic acid) known as niacinamide (nicotinamide). Both niacin and niacinamide are commonly referred to as vitamin B3. The biochemistry of vitamin B3 is well known in that it is involved in some two hundred enzymatic reactions, mostly including dehydrogenases within the human body. Its active forms or its coenzymes are both nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP).

Supplemental Niacinamide Mitigates Anxiety

Symptoms: Three Case Reports

Jonathan E. Prousky, N.D., FRSH1

1. Chief Naturopathic Medical Officer, Associate Dean of Clinical Education & Associate Professor of Clinical Nutrition, The Canadian College of Naturopathic Medicine, 1255 Sheppard Avenue East, Toronto, ON Toronto, M2K 1E2.

A vitamin important in carbohydrate metabolism, the formation of testosterone and other hormones, the formation of red blood cells and maintaining the integrity of all cells. Niacinamide helps your body to utilize protein, fats and carbohydrates. It is necessary for a healthy nervous system and digestive system. Niacinamide is a peripheral vascular dilator, which may be helpful in hypertension. Deficiency may cause listlessness, headache, weight loss, loss of appetite, rough cracked skin and ulceration.

Niacinamide may be helpful in poor appetite, ulcerative colitis, chronic diarrhea, disorders of the digestive system, as an insect repellent, in diabetic neuropathy, AIDS, maintaining a positive mental attitude, enhancing learning abilities, heart disease, alcoholism, stress, improving athletic performance and aging. It may also be used for canker sores (syphilis), immuno-depression, memory loss including Alzheimer's disease, vision problems such as cataracts and glaucoma, motion sickness and increasing energy.

Therapeutical uses of niacinamide

The therapeutic uses that are now well established are as follows:

    . Treatment ADHD in children & adults

A study comparing the benefits of high dose niacinamide compared to diazepam came up with the interesting result that niacinamide was more effective. Studies show children with ADHD do not get over this problem when they become adults unless they continue to take niacinamide. Niacinamide is fascinating stuff. Apparently the drug companies developed clonazepam (valium) as a result of trying to copy the structure of niacinamide.

  • Treatment of fatigue

For the reasons given above, low B3 will result in fatigue. Any condition associated with poor mitochondrial function, such as chronic fatigue syndrome, any organ failure, and any neurological disease such as Parkinson's disease, may well benefit from high doses of NAD.

  • Arthritis

Work done by Dr William Kaufman in the 1940s and written up in his book "The Common Form of Joint Dysfunction" demonstrated that many forms of arthritis can benefit from high dose B3. Kaufman was insistent that the full daily dose of as much as 3000 - 5000 mg be given in many small divided doses throughout the day. He got excellent results. This is an intervention well worth trying. See Arthritis - Nutritional treatments

  • Schizophrenia and Psychosis

Dr Abram Hoffer routinely uses high dose niacinamide, up to 3 grams daily, with excellent results for patients suffering from psychosis. It may take some months, or even years, to get the full benefit, but normal mental health can be restored. This is taken in conjunction with other nutritional supplements.

  • Anxiety and mood swings

A study comparing the benefits of high dose niacinamide compared to diazepam came up with the interesting result that niacinamide was more effective.

  • Control of blood sugar levels

I find myself talking more about the control of blood sugar levels than all other subjects put together. It is not just a case of maintaining a low Glycemic index diet. Taking nutritional supplements, reducing allergies, correcting hormonal imbalances and managing stress efficiently are all essential in maintaining normal blood sugar levels. See Hypoglycaemia

  • Parkinson's disease

A trial of high dose niacinamide is well worth it in patients with Parkinson's disease because some will see marked improvements. This may be because niacinamide also has an effect on neurotransmitter levels.

  • Neurotransmitter levels

Niacinamide may be converted by the body back to tryptophan and this is the raw material for the pathway that includes 5-HTP, serotonin and melatonin. This pathway will have profound effects on mood and sleep. So, for example, tryptophan and 5-HTP are very effective in the treatment of depression. Melatonin is obviously essential for quality sleep.

 However, as the higher dosage levels of niacinamide have been cautiously explored in the past 22 months, it has been found in severe and extremely severe joint dysfunction that divided doses of niacinamide totaling 4 or 5 grams (4,000-5,000 mg) per 24 hours are therapeutically superior to the lower dosage schedules which previously had been considered adequate. Even these higher dosage levels of niacinamide may not be optimal for the treatment of joint dysfunction.

After months of continuous, adequate therapy with niacinamide, maximal passive extension of the metacarpophalangeal joint reached 100%

Niacinamide, also called niacin, nicotinamide and vitamin B3 is an important vitamin for carbohydrate and protein metabolism in the body. Niacinamide has been well known for its role in boosting good cholesterol or HDL in the body. But niacinamide's role as a skin rejuvenating ingredient is not so well known. Studies have shown that niacinamide can be effective at treating acne, fading hyperpigmentation, and improving skin barrier functions. Gentler than retinoids and glycolic acids, the ingredient is a great alternative to standard skin rejuvenating treatments.

I Paul OBrien take (3) 500mg tablets morning, noon & night and it has dramatically helped my range of motion, reduced pain & make my skin look much better.

Doctors do not check B3 levels because it costs over $1000 and is not covered by insurances. If vitamin B3 is a possible problem it is better to just take the pills and see how well it works.

B3 helps people a lot to stop smoking.  B3 reduces alcohol consumption.

I have known a lot of people anxiety disorders and obsessive-compulsive personality symptom who have made life miserable for me & others that I feel could have been cured with niacinamide.

I buy  from NSI Vitamin B3 Niacinamide -- 500 mg - 200 Capsules Retail price: $15.95 Our price: $6.39  59% off   I buy 5 bottles at a time to reduce shipping costs.

Stop smoking the easy way!

 Any supplements that will calm the nerves and anxiety would do. While stopping addiction might seen to be difficult, reducing anxiety would be a more practical approach.

The addiction to cigarettes is due to the nicotine, but what is interesting is the chemical similarity with only one oxygen molecule less, which is nicotinic acid or also goes by another name called niacinamide, which is vitamin B3.

Therefore taking some vitamin B complex plus maybe 100 mg of niacinamide supplements more may displace the nicotine due to chemical similarities. The vitamin B3 if taken at larger than average dose do have the tendency to reduce anxiety and hence, possible addiction to nicotine.

http://www.helpyourselfcommunity.org/features/niacinamide%E2%80%99s-potent-role-alleviating-anxiety-its-benzodiazepine-properties-case-report

Does Niacinamide work for anxiety? Well, there are a few reasons why I think it might be worth a try. Firstly, a proper scientific study found that Niacinamide had anti-anxiety (anxiolytic) effects in animals (Tallman JF, Paul SM, Skolnick P, Gallager DW (1980).

Some  people have hypothesized that Niacinamide works on the same receptors as Benzodiazepines like Valium and Xanax. Relying on drugs might not be that wise, why not also consider Niacinamide to help you relax and cure anxiety.

Further more, if the body does not get enough Vitamin B3 through diet, it can make it from Tryptophan. This is not good for anxiety sufferers as Tryptophan is the amino acid the body uses to make the good mood chemical Serotonin, a lack of which causes anxiety and depression. Therefore it might be the case that taking on more B3 in the form of Niacinamide lessens the necessity to divert Tryptophan away from Serotonin and therefore boosts mood and calm anxiety that way.

On top of that, B Vitamins are essential for correct brain and nervous system functioning.

Lastly, other people with anxiety that have expressed an opinion swear by Niacinamide. Not everyone of course, nothing works for everyone. But when someone else has tried something and had success it is generally worth a shot!

I Paul OBrien take (3) 500mg tablets morning, noon & night and it has dramatically helped my range of motion, reduced pain & make my skin look much better.

Doctors do not check B3 levels because it costs over $1000 and is not covered by insurances. If vitamin B3 is a possible problem it is better to just take the pills and see how well it works.

B3 helps people a lot to stop smoking.  B3 reduces alcohol consumption.

I have known a lot of people anxiety disorders and obsessive-compulsive personality symptom who have made life miserable for me & others that I feel could have been cured with niacinamide.

 

You may want to try these vitamins and minerals for several months to cure ARTHURITIS before you go to get a knee replacement, hip replacement or back operation as the these seem to cure these problems and completely eliminate pain as it did for me.

 

These food supplements will  probably cure kidney problems, liver problems, sugar diabetes, stop and possibly reverse Alzheimer’s and even cancer.

Strontium Bone-building Discovery that Cuts Your Risk of Fracture by as Much as 59% in one year and recent studies show it even grows Cartlidge between bones to eliminate pain.

Click here to find What and where to Purchase and how much to take to cure almost all health problems even those considered by doctors as incurable.     

 Take 1AM and 2 Pm until temperature is 98  first thing in the morning and 98.6 by noon of Desiccated thyroid capsules to help cure arthritis, hypothyroid,  diabetes, Alzheimer's,  and stops over 90% of heart attacks , lowers blood pressure, lowers LDL & triglycerides, raises HDL stops sugar diabetes from causing blindness, hearing loss, sleep troubles, legs cut off due to gangrene, balancing problems, hair loss, loss of smell. Wow desiccated thyroid can cure or keep these problems from happening. Note: this is needed by almost all elderly since 1 in 2 people 80 years old get Alzheimer’s.  Click on the blue to learn if you need desiccated thyroid and how much to take.  The picture is of a doctor who was taking useless Centroid as prescribed by most doctors and changed to desiccated thyroid, 

Take this report to your doctor and get his approval and have him check blood work to see if you need iron, potassium and zinc as these are very important.

Studies show this "forgotten" nutrient can build stronger, denser bones than calcium and vitamin D and eliminate replacements.

Post-menopausal women normally lose about 1% of their bone per year, but the Strontium ranelate studies are showing 3 year bone growth of 8.1 %! These exciting results were published in large phase three study that followed two other very positive multinational strontium clinicals. In this most recent study, 1,649 postmenopausal women with osteoporosis who had had at least one vertebral fracture were randomized to receive either strontium ranelate or placebo for three years. Both groups also took calcium and vitamin D with the strontium to achieve these results.

By maintaining dense, sturdy bones, you can stay active and independent into your 80s, 90s, and beyond. You can travel, play with your grandchildren, visit museums, work in your garden — or do whatever it is you love to do. You can also handle your own driving, grocery shopping, laundry, and other household chores without being dependent on others.

But the frightening truth is, 1-in-2 women and 1-in-4 men over age 50 will suffer at least one bone fracture in their lifetime. That's more than 1.5 million fractures caused by bone loss each year. Strontium May Spare More arthritis Knees from Surgery. By: HEIDI SPLETE, Rheumatology News Digital Network

WASHINGTON – A daily dose of strontium ranelate was associated with a significant delay in joint space narrowing in adults with symptomatic primary knee osteoarthritis, based on data from the phase III Strontium Ranelate Knee Osteoarthritis Trial (SEKOIA). I have been taking strontium for over year and a half and my knees which were very sore have no pain so Cartlidge must’ve grown back into those knees.

 

I buy  from NSI Vitamin B3 Niacinamide -- 500 mg - 200 Capsules Retail price: $15.95 Our price: $7.24  59% off   I buy 5 bottles at a time to reduce shipping costs.

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